Word: endostatin
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Folkman's lab has previously reported successful experiments using the anti-angiogenic proteins endostatin and angiostatin on tumors in mice. In those experiments, the substances were shown to cause tumors in mice to regress to microscopic size...
According to officials at the Children's Hospital, the first phase of clinical trials in humans with endostatin will begin in Boston in late September. Angiostatin is expected to enter Phase I clinical trials next year...
...Endostatin has been shown to induce the complete regression of tumors whereas other drugs may only prevent metastasis or halt growth when used alone...
...theoretically, endostatin patients should be able to undergo long-term treatment with little to no side effects, since the protein occurs naturally in the human body and will therefore not be rejected by the host...
Drugs like endostatin could make very useful and effective treatments for these diseases since, as Folkman says, they are "very safe, like insulin, but also potent...