Word: endostatin
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
...versatile compound is endostatin, a human protein that inhibits angiogenesis, the growth of new blood vessels in the body. In tests reported in 1997 by Folkman, a prominent cancer researcher who pioneered the study of angiogenesis, the drug had reduced and even eradicated tumors in laboratory mice. How? By stunting the growth of capillaries necessary for nourishing the burgeoning mouse tumors...
...cancer cures. When other scientists were initially unable to duplicate those results, questions arose about the validity of Folkman's research. Then in February scientists at the National Cancer Institute, with guidance from Folkman, finally matched his results. Reassured, the N.C.I. gave the go-ahead for clinical trials of endostatin later this year on patients with advanced tumors...
...composition of plaque, the fatty deposit that builds up in arteries and can eventually clog them. Plaque consists of a mix of cholesterol, white blood cells and smooth muscle cells, and as it accumulates, a network of capillaries sprouts from the artery walls to nourish the cells. Could endostatin halt the growth of capillaries and starve the plaque...
...mice on a 16-week "Western diet" that was high in fat and cholesterol, then measured the plaque buildup on the walls of each aorta, the large artery that carries blood from the heart to the rest of the body. Meanwhile, they injected one group of mice with endostatin, another with a different blood-vessel inhibitor called TNP-470 and a control group with an inert saline solution. Twenty weeks later the researchers again measured plaque in the mouse aortas. The results were startling: the endostatin group averaged 85% less plaque buildup and the TNP-470 group 70% less than...
EntreMed can now attempt to produce angiostatin itself, as it does endostatin, or license it to another company...