Word: proteins
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Biology professor Susan L. Lindquist was honored with a doctor of science. Lindquist, who received her Ph.D. in biology from Harvard in 1977 , teaches at MIT and focuses her research on complex molecular protein folding and the phenomenon's role in cancer, cystic fibrosis, and other diseases...
...structure-based drug design, the three-dimensional structure of the designated biological target determines the components of the treatment while fragment-based approaches in drug discovery employ physical techniques to determine how fragments bind to protein targets...
...Fragment-based screening involves highly-focused chemistry,” he said. “It tailors molecules to bind to a protein target of interest and covers more chemical space, while identifying hits not obtained in other screens...
Fesik said that his research had encountered some skepticism, as other scientists’ previous attempts to create treatments dependent on protein-protein interactions have failed. To combat this perception of the direction his research took, he outlined pre-clinical activities and the multiple approaches to treatment employed in their studies, which he said improved the odds of success...
...trying to identify useful lead molecules and compounds in clinical trials,” he said. “My lab is focused on developing improvements in fragment-based approaches and applying them to target proteins involved in protein-protein interactions...