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Biology professor Susan L. Lindquist was honored with a doctor of science. Lindquist, who received her Ph.D. in biology from Harvard in 1977 , teaches at MIT and focuses her research on complex molecular protein folding and the phenomenon's role in cancer, cystic fibrosis, and other diseases...

Author: By Xi Yu, CRIMSON STAFF WRITER | Title: Harvard Awards 10 Honorary Degrees | 5/31/2010 | See Source »

...structure-based drug design, the three-dimensional structure of the designated biological target determines the components of the treatment while fragment-based approaches in drug discovery employ physical techniques to determine how fragments bind to protein targets...

Author: By Barbara B. Depena, CRIMSON STAFF WRITER | Title: Harvard Medical School Lecture Explores Cancer Treatments | 5/25/2010 | See Source »

...Fragment-based screening involves highly-focused chemistry,” he said. “It tailors molecules to bind to a protein target of interest and covers more chemical space, while identifying hits not obtained in other screens...

Author: By Barbara B. Depena, CRIMSON STAFF WRITER | Title: Harvard Medical School Lecture Explores Cancer Treatments | 5/25/2010 | See Source »

Fesik said that his research had encountered some skepticism, as other scientists’ previous attempts to create treatments dependent on protein-protein interactions have failed. To combat this perception of the direction his research took, he outlined pre-clinical activities and the multiple approaches to treatment employed in their studies, which he said improved the odds of success...

Author: By Barbara B. Depena, CRIMSON STAFF WRITER | Title: Harvard Medical School Lecture Explores Cancer Treatments | 5/25/2010 | See Source »

...trying to identify useful lead molecules and compounds in clinical trials,” he said. “My lab is focused on developing improvements in fragment-based approaches and applying them to target proteins involved in protein-protein interactions...

Author: By Barbara B. Depena, CRIMSON STAFF WRITER | Title: Harvard Medical School Lecture Explores Cancer Treatments | 5/25/2010 | See Source »

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