Word: endostatin
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...Endostatin is the first of several anti-cancer drugs under evaluation which prevent angiogenesis, the growth of new blood vessels in the body. Doctors hope that, by stopping the growth of blood vessels around a cancerous tumor, the drug can shrink tumors and prevent the cancer from spreading...
This week, doctors will begin testing endostatin, a cancer-fighting drug developed from Folkman's research, on human beings for the first time...
Susan Craig, spokesperson for the Children's Hospital, Boston, where Folkman conducts his research, says that endostatin has been successful in studies on mice, reducing cancerous tumors to nearly microscopic size with no observable side effects...
...Although endostatin might prevent blood vessels in the body other than those around a tumor from forming, Corey said normal adult tissue can remain healthy without angiogenesis. Only tumors would be adversely affected, he said...
...first endostatin testing on humans will be conducted by Dana-Farber/Partners CancerCare--a coalition of Massachusetts General Hospital, Brigham and Women's Hospital and the Dana-Farber Cancer Institute. Two other institutes, one in Houston and another in Wisconsin, will begin testing the drug later in the year...