Word: paxil
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...abnormal bleeding. Patients taking drugs that strongly inhibit reuptake of serotonin--a neurotransmitter that aids both mood and blood clotting--were at least twice as likely to be hospitalized for bleeding in the brain, uterus and other sites than patients taking weaker drugs. So-called SSRIs, including Prozac and Paxil, were among the strongest drugs. The risk is small, however, and most serious for patients already at elevated risk for bleeding...
...antidepressants in question are Selective Serotonin Reuptake Inhibitors (SSRIs) and are commonly known by their brand names—Prozac, Paxil, Zoloft and others. On the whole, they have reliably shown to be successful in treating depression, obsessive compulsive disorder and anxiety. Unfortunately, the very real disturbances of the depressed child or adolescent deprived of these medications have been all but pushed aside amid the discussions of the thickness and placement of the label warnings. A child or adolescent who has been identified as having depression accompanied with a high risk of suicidality will be much more likely to entertain...
...when they have mended—saved—innumerable lives in the past. Nor is it constructive in any way to sloppily cover all SSRIs under one homogeneous red flag. Factors vary from one SSRI to the next, and have direct bearing on the risk of suicidal tendencies. Paxil has a much shorter life than Prozac, for instance, and therefore leaves the body much sooner, leading to a “rebound” period during which suicidality is more likely to occur...
...lent a hand at Heathrow late last week - a great way to spend a summer holiday. - By Adam Smith The Spitzer Treatment Britain's GlaxoSmithKline (GSK) reached a $2.5 million settlement with New York Attorney General Eliot Spitzer over allegations that it withheld information about the safety of antidepressant Paxil. GSK also agreed to publish online the results of all its clinical trials since December 2000. Spitzer sued the firm in June, claiming it failed to release data suggesting Paxil could increase suicidal tendencies in children...
...that's why there is a movement afoot to require researchers to register all clinical trials when they start. This isn't a new idea, but it's been given new urgency by, among other cases, the example of GlaxoSmithKline (GSK) and its antidepressant Paxil. While data that showed Paxil could help depressed adolescents were published in the Journal of the American Academy of Child & Adolescent Psychiatry, the results of another trial, which raised concerns about children having suicidal thoughts while on Paxil, were not submitted for publication. (GSK points out, however, that the negative results were presented...