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...Trauma of War Before the advent of SSRIs - Lilly's Prozac was the first to be approved by the FDA, in 1987, followed by Zoloft from Pfizer, Paxil from GlaxoSmithKline, Celexa from Forest Pharmaceuticals and others - existing antidepressants had many disabling side effects. Impaired memory and judgment, dizziness, drowsiness and other complications made them ill suited for troops in combat. The newer drugs have fewer side effects and, unlike earlier drugs, are generally not addictive or toxic, even when taken in large quantities. They work by keeping neural connections bathed in a brain chemical known as serotonin. That amplifies serotonin...

Author: /time Magazine | Title: America's Medicated Army | 6/5/2008 | See Source »

Popular antidepressants including Prozac and Paxil have little impact on most patients, according to a comprehensive review of newly released data from trials that were conducted before the drugs were approved...

Author: /time Magazine | Title: Antidepressants Hardly Help | 2/26/2008 | See Source »

...Researchers from the U.K., U.S. and Canada analyzed results for fluoxetine (better known by the brand name Prozac), venlafaxine (Effexor), nefazodone (Serzone) and paroxetine (Paxil or Seroxat) - all members of a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). The researchers' paper, published this week in the journal PLoS Medicine, claims that only patients who are diagnosed "at the upper end of the very severely depressed category" get any meaningful benefit from the widely prescribed drugs. For the others, the paper says, antidepressants are barely more effective than a placebo (although patients suffering from depression, like those suffering...

Author: /time Magazine | Title: Antidepressants Hardly Help | 2/26/2008 | See Source »

...depressed, we're probably also seeking pharmacological help. By aggregating the traffic to the websites of the top antidepressants and charting visits to those sites over the last three years, a very interesting pattern emerges. The spike in traffic to the official websites for drugs like Lexapro, Prozac, Paxil and Cymbalta occurs in late October and early November, two weeks ahead of the height in searches on "depression." It's almost as if people anticipate their holiday depression and start shopping early for their drug of choice...

Author: /time Magazine | Title: The Most Depressing Day of the Year | 1/18/2008 | See Source »

...adults undergo CBT, which teaches patients to view their own thoughts differently--to see a failed date, for instance, not as proof that "I will never be loved" but as a minor thing that didn't work out. Thirteen other patients received paroxetine (the generic form of the antidepressant Paxil). All experienced comparable improvement after treatment. Then the scientists scanned the patients' brains. "Our hypothesis was, if you do well with treatment, your brain will have changed in the same way no matter which treatment you received," said Toronto's Zindel Segal...

Author: /time Magazine | Title: The Brain: How The Brain Rewires Itself | 1/19/2007 | See Source »

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