Word: inhibitors
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...said that analysis found that mutations at solely sites 46 or 82 lead to weak resistance to Indinavir, an HIV protease inhibitor, but mutations at site 54 alone have no effect. More surprisingly, mutations at sites 54 and 45 actually made the virus even more susceptible to the drug...
...disease - even combined, its two agents are considered too weak to keep the virus from developing resistance. The pairing was effective as a protective safety net, however, and in 1998, the Centers for Disease Control and Prevention recommended Combivir, either alone or together with a more powerful protease-inhibitor medication, for health care workers who were exposed to blood or fluid that might contain HIV. Some studies showed that coupling the drugs could reduce risk of infection in health care workers by as much...
...cells form a tumor and begin to grow uncontrollably, they need to induce the formation of new blood vessels to bring them oxygen and nutrients—a process known as angiogenesis. A team of researchers at Massachusetts General Hospital has discovered that the main effects of an angiogenesis inhibitor in treating glioblastoma, a severe kind of brain tumor, stem from the reduction of brain swelling, rather than any effect on tumor growth. In these tumors, blood vessels can be leaky, which causes swelling in the brain known as edema. This, in turn, can cause drowsiness, loss of consciousness...
...Chicago are about to test one such drug, fenobam, as a treatment for Fragile X. Bear, meanwhile, has founded a company called Seaside Therapeutics that hopes to begin human safety tests of another drug as early as next year. Both researchers believe that a safe and effective mGluR5 inhibitor would help both children and adults with Fragile X Syndrome, though drug treatment early in childhood would seem to offer the most promise...
...allow for further development in the future. Petersen, who noted that he would like to add mechanisms for quickly posting legislation and providing educational resources to students in a second phase of improvements to come later, said that the unwieldy coding of the previous Web site was a primary inhibitor to improvements in the past. —Staff writer Christian B. Flow can be reached at cflow@fas.harvard.edu...