Word: paxil
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...recent cases involving off-label sales of prescription drugs, Neurontin and Paxil, are rekindling debate about whether drugmakers are generating profits at the expense and health of consumers. Since 2001, pharmaceutical companies have paid the U.S. government more than $2 billion to resolve charges of fraudulent sales and marketing tactics (including a record $875 million that TAP Pharmaceutical Products paid as a settlement in 2001 over kickback schemes to get doctors to prescribe its prostate-cancer drug Lupron). Almost every major firm is now being investigated. Says T. Reed Stephens, a former federal prosecutor who brought several cases against...
...figuring out what to do has grown more confusing. One of the best tools for fighting depression is the so-called SSRI class of drugs, including Prozac, Paxil and Zoloft. But evidence has been mounting that these relatively safe medications might trigger suicidal thoughts in some kids. While there's no proof that the drugs have actually caused any suicides, British authorities pretty much banned everything but Prozac last December for children under 18. And in March, the FDA warned that anyone taking antidepressants, including Prozac, should be monitored for emotional agitation...
...says Carol Glod, director of developmental studies at McLean Hospital in Belmont, Mass. "We just haven't studied antidepressant drugs in kids enough to make many definitive statements." Part of the problem is that the brain chemistry of kids is different from adults'. Prozac works for both groups, but Paxil seems to work only for grownups. Kids, moreover, are amazingly responsive to placebos. While 70% of kids get better on Zoloft, for example, 60% improve on sugar pills...
...urged the manufacturers of 10 popular antidepressants to issue new, more stringent warning labels. The drugs named in the advisory are Prozac, Zoloft, Wellbutrin, Zyban, Paxil, Celexa, Effexor, Serzone, Luvox and Remeron. Together these pills racked up sales of about $12 billion worldwide in 2002. Some experts believe that it was their very popularity that concerned the FDA. Many doctors, the agency apparently fears, are giving out the pills too freely, without adequate monitoring...
Depression and physical pain often go hand in hand, and new research suggests why it's important to recognize and treat both. In a group of 573 patients taking Prozac, Paxil or Zoloft, 24% were still not responding to the antidepressants after three months of treatment. The drugs were most likely to fail those who were in pain at the onset of treatment; the worse the pain, the less the drugs worked. The odds of a poor response were twice as high for patients in moderate pain and three to four times as high for those in severe pain...