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Researchers announced this week the early trial results of a new vaccine to fight cocaine addiction - a compound that, by vaccine standards, was only mildly effective but served as an important proof of concept that vaccination against addiction could work...
...Vaccines are one of our top priorities," says Dr. Nora Volkow, director of the National Institute on Drug Abuse (NIDA), which helped fund the study and will finance a larger study of the cocaine vaccine next year. In September, NIDA also granted $10 million for a clinical trial to the makers of NicVAX, a nicotine vaccine that works similarly to the cocaine vaccine - by stimulating the immune system to create antibodies that bind to drug molecules and prevent them from entering the brain. (Because people don't generally make natural antibodies to cocaine, the cocaine vaccine combines a cocaine molecule...
...vaccine produced a strong antibody response in 38% of the 55 people who received all five doses. When antibody levels were highest - during weeks 9 through 16 of the trial - these participants used significantly less cocaine (as measured by urine samples taken three times a week) than either the placebo group or those who did not produce sufficient antibodies. Overall, cocaine use was reduced by at least half in 53% of the people who produced a strong antibody response, compared with 23% of those who had a weaker antibody response. That's far from abstinence, although reduction in drug...
...have no reason to believe," says Kevin Downing, a senior Justice Department tax trial lawyer, "that we would have had any other means to have disclosed what was going on but for an insider in that scheme providing detailed information, which Mr. Birkenfeld did." (Read "Calling All Whistle-Blowers! The SEC Wants...
...three children in a 1991 house fire in Corsicana, Texas. In September, Willingham's story was detailed in a New Yorker investigative report by David Grann. It details the conclusions of two noted experts that the fire was accidental and that the arson evidence presented at Willingham's trial was not based on science. "The New Yorker's investigation lays out this case in its totality and leads to the inescapable conclusion that Willingham was innocent," Scheck says. (Read about the decline in death sentences in Texas...