Word: trial
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...vaccine was administered in two stages. First the ALVAC vaccine, which uses a Frankenstein virus of canarypox and HIV, was used as a primer dose, then AIDSVAX was administered as a "booster" to improve the body's immune response to the first shot. Half of the trial's participants received the combination vaccine, while the other half received a placebo. In the final analysis, 74 of the 8,198 placebo recipients became infected with HIV, compared with 51 of 8,197 participants who received the vaccine regimen...
...million, six-year trial, which involved more than 16,000 people in Thailand - the largest AIDS-vaccine trial ever conducted - found that an experimental vaccine was 31% effective in preventing HIV infection. The volunteer group in the study was representative of the general Thai adult population, including low-risk, heterosexual adults. Calling the results of the trial a "significant scientific advance," officials at the World Health Organization said the results reinvigorated the stalled quest for a vaccine against AIDS, which is estimated to kill some 2 million people globally each year. (See the top 10 medical breakthroughs...
...efficacy is a modest one. But it's the first time we've seen a positive signal of efficacy in a human trial of any HIV vaccine. That's an exciting result in a field that has been characterized by disappointments for two decades," says Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases (NIAID), which provided major funding and other support for the Thai trial...
...scientists working on the trial, led in Thailand by the U.S. Army and the Thailand Ministry of Public Health, said they were baffled as to why the two seemingly ineffective vaccines appeared to work together. Another mystery was that the people who became infected with HIV developed roughly the same amount of virus in their blood whether they got the vaccine or the placebo. Typically a protective vaccine would lower a patient's so-called viral load, a criterion that physicians use as the main indicator of HIV infection. The outcome of the trial of RV144 suggests that scientists...
...President Obama, in a sop to Republicans, spoke favorably of medical malpractice reform in last week’s speech. But his proposed action on this front (the creation of a committee to make recommendations to Congress) is a cop-out. This is not surprising, given trial lawyers’ support for the Democratic Party. Malpractice lawsuits, while a necessary recourse for victims of medical errors, impose a cost on health-care providers. Fearing lawsuits, doctors buy expensive malpractice insurance and order unnecessary tests. Juries, lacking medical expertise, are generally poor assessors of guilt: A study in the New England...