Word: trial
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Perhaps, but the release of the trial's full data has not quelled the early criticism that bubbled up around it. Some researchers contend that the second and third analyses of the data - including the "per protocol" analysis, which included only the 12,450 volunteers who received all six vaccine or placebo injections and completed the trial and the "intent to treat" analysis, which included everyone except the previously HIV-infected participants - show that the results are not statistically significant. Both analyses found the vaccine to be just 26% effective - that figure is empirically low, but further, the analyses relegate...
Still, after more than 25 years of virtually futile AIDS-vaccine research, the investigators involved in the Thai trial believe that their findings, while admittedly "modest," offer unprecedented leads to follow. "To quote from our recent history, this is a 'Yes we can' moment," Michael says. "It is not a public health breakthrough, [and] there is not a vaccine around the corner. But the door has finally been cracked open...
...manner in which the study was presented to the public - is secondary to what the research brings to the battle against HIV. "Let's not get hung up on tangential concerns, and stay focused on everyone's main priority: working our way toward getting a vaccine," Bernstein says. "This trial isn't the big bang. It isn't perfect, and [it] has only provided points of information that must be examined, pursued and - yes - hotly debated. But that's what science is about, and we've got more now to go on than we did before...
Despite the guarded optimism of researchers, AIDS activists in the U.S. and Europe resent what they refer to as the "hype" surrounding the trial's results, which they think continues to raise questions - unnecessarily - about its significance. But specialists like Frahm say that was bound to happen. Against the relentless silence in the field of AIDS-vaccine research, even the tiniest signal from a lone Thai trial can sound like a fog horn...
Call it China's trial of the 21st century. Not since Mao Zedong's wife and her fellow members of the reviled Gang of Four were tried in 1980 has a courtroom trial so captured the attention of the nation. For one thing, there's the sheer scale of the operation that brought more than 30 defendants to court this week: a crackdown on the alliance of criminal gangs and their corrupt official collaborators who have terrorized a huge metropolis for years. Thousands of suspects were questioned, some 1,500 were arrested, bribes in the tens of millions of renminbi...