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...AIDS-vaccine syringe half full - or virtually empty? That's the question researchers continue to contemplate following the release on Tuesday of the full trial data of a vaccine tested against HIV infection in Thailand...
Nonetheless, many AIDS experts applauded the findings as a crucial starting point for further research. Some say that as slight as it was, the vaccine benefit discovered in the trial may eventually help scientists develop a workable AIDS vaccine - a goal that has eluded them for more than two decades. "Having this signal - even if it's weak and even if we're debating whether it's a real signal or not - is a source of great hope," said Nicole Frahm, an HIV specialist at the Fred Hutchinson Cancer Research Center in Seattle, while attending the annual AIDS vaccine conference...
Detailed simultaneously on Tuesday at the Paris meeting and in a paper in the New England Journal of Medicine, the U.S. government-sponsored trial (both the National Institute of Allergy and Infectious Diseases and the U.S. Army provided funding) involved about 16,400 Thai volunteers. Half were given six injections comprising two AIDS vaccines, neither of which had proved effective in previous studies; the other half of the study group was given a placebo. (Read "The Flip Side of Placebos: The Nocebo Effect...
...approach was 31% effective in preventing HIV infection: 51 of the roughly 8,200 people who had been inoculated eventually acquired HIV, compared with 74 people in the placebo group. The analysis that resulted in the 31% figure, however, included study participants who became infected with HIV before the trial concluded and did not complete the entire vaccination schedule; it also factored out participants who were discovered to have been HIV-positive before the trial began. At a press conference at the Paris meeting, Dr. Nelson L. Michael, a virologist with the U.S. Military HIV Research Program, which helped...
Tassopoulos’ early career has proven to be a trial by fire, with the Crimson taking on a number of talented non-conference teams, including UMass, Michigan, and BU in consecutive weeks. As expected, such talented opponents have created a barrage of shots, and Tassopoulos has been forced to respond. The rookie has amassed 99 saves for an average of 8.25 per game, up from Harvard’s 5.41 a year ago and good for 9th in the nation. Tassopoulos has even notched 23 saves in a single contest, at then-No.5 Connecticut on Sept...