Word: inhibitors
(lookup in dictionary)
(lookup stats)
Dates: all
Sort By: most recent first
(reverse)
While the first two inhibitors work to prevent the virus from infecting a host cell, the protease inhibitor class of drugs works to disable protease, an enzyme occurring naturally in every living organism that works to digest proteins...
...movie. That victory has gone largely unchallenged, except by columnist and author Michael Fumento who, as early as 2000, documented some of the firm's questionable tactics. The suit, on behalf of Hinkley, California residents, focused on an ionized form of chromium called chromium-6, a rust inhibitor that was carelessly dumped by the giant utility, Pacific Gas & Electric, and seeped into the groundwater used by the town's residents. In bringing suit against PG&E, Brockovich's law firm charged that chromium-6, in addition to causing cancer, was responsible for disorders ranging from rashes and nosebleeds to lupus...
...That?s what Dr. Rolf Hilgenfeld and his associates in Germany are trying to do. The researchers examined the coronavirus genome and developed a theoretical compound that could act as a protease inhibitor. By searching for compounds with a similar chemical structure, they quickly found an existing cold drug called AG7088, developed but never marketed by the drug company Pfizer, that might similarly interdict the coronavirus? protease?giving researchers a potential weapon against SARS. ?The compound itself will probably not be used for a drug to treat SARS,? said Dr. Hilgenfeld. ?But it is a very good starting point...
...even with mainland China?s somewhat lax regulations for drug approval, it will likely be a year or more before the peptide fusion inhibitor could be used for patients. And that assumes the coronavirus won?t evade the treatment through mutation. Dr. Edison Liu, executive director of Singapore?s Genome Institute, which recently published a study comparing the coronavirus genome in several different regions, says, ?If the receptor interaction is changed so that the virus uses a different receptor or has a different region to which it binds, it?ll evade the peptide...
...prevents the formation of new blood vessels that feed tumors, reduces inflammation and kick starts the body's immune system. While existing anticancer agents kill off lymphocytes and white blood cells, which control immune and inflammatory responses, thalidomide has no toxic effect on them. It is also a potent inhibitor of cell movement, thus preventing inflammation around a tumor. Though thalidomide does have side effects, like dizziness and tingling in the toes, it is more gentle than existing therapies...