Word: resveratrol
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...agents for extending life, other drugs may be further along in the pipeline - resveratrol, for one, which has also prolonged life in lab mice. But the new finding by Strong and his colleagues "more clearly identifies the [target of rapamycin] pathway as important across species." It may guide researchers to target different proteins in the same pathway. "If those proteins react the same way to extend lifespan, then we might be able to get rid of unwanted side effects," says Strong...
Medical School pathologist David Sinclair and researchers at a Cambridge pharmaceutical firm he helped found said they developed a chemical 1,000 times more potent than the resveratrol found in red wine and grapes...
...team led by Sinclair previously discovered that resveratrol can stimulate the SIRT1 gene, which controls aging. But it took them several years to develop a compound powerful enough to potentially be used as a drug for humans...
...work is a breakthough because it shows you can develop drug-like molecules that are one thousand time more potent than resveratrol,” Sinclair said in a phone interview yesterday. The report was published in yesterday’s edition of the journal Nature...
...related illnesses that the resveratrol-like compound may help treat include type 2 diabetes—by far the most prevalent kind of diabetes among the 20 million Americans suffering from the disease...