Word: proteins
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...those tests take you only so far. Suppose you could do more than just collect the enemy cells. Suppose you could interrogate them for information. That's what the new tests make possible. Researchers are starting to identify, for example, proteins on the surface of tumor cells that might signal a faster-growing, more aggressive type of cancer. Other protein signatures may hint at a more advanced tumor that is poised to metastasize. Both can help doctors craft more personalized therapies that match the right treatments to the right patients at the right time, improving effectiveness, lowering the costs...
...look at tumors for changes at the DNA, RNA and protein levels," says Dr. Gordon Mills, chair of systems biology at the M.D. Anderson Cancer Center in Houston. "It certainly gives us a way of looking at what is happening inside a tumor, and that's very exciting...
...immediate obstacle to translating the results to human cells involves the way that the scientists turned back time on the mouse skin cells. They used a retrovirus vector, piggybacking the genes for the growth factors and proteins onto this infectious ferry. Retroviruses, however, like HIV, can cause infectious diseases and are not always easy to control, so before testing this approach in humans, researchers need to find other modes of transport for the critical compounds. The good news is that they need the genes to churn out their proteins for a only brief period of time, so using less virulent...
...seared salmon pasta and half a rack of baby back ribs from Friday's "Right Portion, Right Price" menu. Unlike Ruby Tuesday, Friday's and Cheesecake Factory are cutting prices along with meal size, so each dish was a few dollars cheaper than the larger entrées. Though the protein was two-thirds the size of that in a normal Friday's meal, the side dishes were the same size as always. We were already planning on ordering some potato skins. To our surprise, however, when we finished, we were full, but not stuffed. And we ordered dessert and drinks...
Still, triptans have dramatically changed the lives of millions of migraine sufferers and opened up promising areas of research. Scientists have discovered that triptans, besides affecting serotonin pathways, also directly block one of the stimulatory proteins released by the nerve endings in the dura. New compounds that target this protein, dubbed cgrp, are being tested in Europe. One big problem, says Lars Edvinsson of Lund University in Sweden, "is that the drug can be given only intravenously. We need a cgrp blocker that works as a tablet...