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...that do not involve embryonic cells. That deserves to be called a breakthrough. The new pups, whose creation in two separate labs in China was announced in July, were the first to be bred from induced pluripotent stem (iPS) cells. These are adult cells (usually skin cells) that scientists reprogram back to their embryonic state by introducing four genes. The reprogrammed stem cells are then programmed again to develop into mice, a feat that has been accomplished before only using embryonic stem cells. Breeding an entire mouse that is itself capable of reproducing - as the mice...

Author: /time Magazine | Title: TIME's Top 10 Medical Breakthroughs of 2009 | 12/8/2009 | See Source »

...Japanese scientist Shinya Yamanaka first induced stem cells from adult mouse fibroblasts—cells most commonly found in connective tissue—by using viruses to insert four genes into the fibroblasts. These genes worked to reprogram the cells into pluripotent stem cells...

Author: By CAROLINE A. SOLOMON, CONTRIBUTING WRITER | Title: HSCI Nears Stem Cell Creation Goal | 10/13/2009 | See Source »

...started offering optimism training, there's been a thriving industry in the kind of thought reform that supposedly overcomes negative thinking. You can buy any number of books and DVDs with titles like Little Gold Book of YES! Attitude, in which you will learn mental exercises to reprogram your outlook from gray to the rosiest pink: "affirmations," for example, in which you repeat upbeat predictions over and over to yourself; "visualizations" in which you post on your bathroom mirror pictures of that car or boat you want; "disputations" to refute any stray negative thoughts that may come along. If money...

Author: /time Magazine | Title: Overrated Optimism: The Peril of Positive Thinking | 10/10/2009 | See Source »

...true power of reprogramming, however, does not stop with the stem cell. This summer, Melton flirted with the rules of biology once again when he generated another batch of history-making cells, switching one type of adult pancreatic cell, which does not produce insulin, to a type that does - without using stem cells at all. Why, he thought, do we need to erase a mature cell's entire genetic memory? If it's possible to reprogram cells back to the embryo, wouldn't it be more efficient in some cases to go back only part of the way and simply...

Author: /time Magazine | Title: Stem-Cell Research: The Quest Resumes | 1/29/2009 | See Source »

...Melton’s research is the first to demonstrate that scientists may be able to use chemicals instead of viruses and genes to reprogram adult cells into a more mutable state, a development long hoped for by stem cell researchers...

Author: By June Q. Wu, CRIMSON STAFF WRITER | Title: Safer Stem Cells on Horizon, Harvard Researchers Say | 10/15/2008 | See Source »

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