Word: librium
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...inventor of the widely used antianxiety drug Valium; at home in Chapel Hill, N.C. Born in Austria and educated in Poland, he began his career with Hoffmann-La Roche Inc. in Switzerland before coming to the U.S. Sternbach collected 241 patents in his career; he also developed the tranquilizer Librium, the sleeping pill Mogadon, Klonopin for epileptic seizures and Arfonad to control bleeding during surgery...
...Darvon), which for the elderly offers no better pain relief than aspirin or Tylenol and is known to be addictive. Yet more than 6% of the seniors surveyed had been prescribed propoxyphene. Even more serious are a variety of modern tranquilizers and hypnotics, such as flurazepam (Somnol) and chlordiazepoxide (Librium). These medicines can lead to falls and hip fractures...
When Halcion was first approved for sale in the U.S. in 1982, doctors thought they had found the perfect sleeping pill. Like its chemical cousins Librium and Valium, it was safer than barbiturates. As an added bonus, Halcion did not linger in the body the way most of its predecessors did, and therefore it did not leave people groggy the next day. Within a few years, the drug, produced by Upjohn of Kalamazoo, Mich., became the most prescribed sleeping pill in the world. In 1990 American pharmacists filled more than 7 million orders. Satisfied customers include Secretary of State James...
When the tranquilizer Valium became the most frequently prescribed drug of the stressed-out 1970s, F. Hoffmann-La Roche reached the peak of good health. Thanks largely to Valium and its sister sedative, Librium, the Swiss-based Hoffmann-La Roche became the No. 1 maker of prescription pharmaceuticals and one of the most profitable companies on earth. But lulled by the success of Valium, whose U.S. patent expired four years ago, the company failed to keep pace in the '80s with such aggressive rivals as U.S.-based Merck and Swiss neighbors Sandoz and Ciba-Geigy. Symbolic of Hoffmann-La Roche...
...called gamma- aminobutyric acid (GABA), a neurotransmitter that moves across the synapses between neurons. GABA homes in on a complex known as the GABA-benzodiazepine receptor. If there are a sufficient number of GABA molecules present in certain areas of the brain, anxiety diminishes. Tranquilizers such as Valium and Librium work by attaching themselves to the receptor and increasing GABA's effectiveness...