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...these genes, two - clusterin and CR1 - are known to interact with the amyloid protein that builds up in the brain of Alzheimer's patients and eventually causes nerve cell death and cognitive problems. Clusterin may be involved in helping to clear away the amyloid that forms in the brain; but another variant of the gene may also allow amyloid to form fibrils, the sticky protein arms that further anchor amyloid plaques to nerve cells, much like a spider web ensnares prey. In late-onset Alzheimer's, it's possible that the body cannot balance these two functions of clusterin...
...that is precisely the power of studies such as these, say experts. They can identify entirely new and unexpected ways of looking at the disease, and eventually ways to treat it. That's particularly important for Alzheimer's and other diseases that are known to arise largely as the result of genetics. While the three new genes contribute a wealth of knowledge about Alzheimer's, they leave considerable room for the discovery of other key genes - experts agree that there are likely legions of genes that may play a role in the development of any given diseases - and, ultimately...
...much has changed in the 50 years since the political journalist Enzo Forcella declared that the Italian newspaper was written for just 1,500 readers: ministers, parliamentarians, party leaders, union bosses and industrialists. News is reported, he wrote, in an "atmosphere of family discussion, with protagonists who have known each other since childhood, exchanging jokes, speaking a language of allusions...
...fact that French private enterprise is surging in the middle of the world's worst economic crisis in 50 years is as surprising as its cause. The motor driving all that bustling start-up action is an innovation known as auto-entrepreneur, a government scheme introduced in January to help would-be bosses bypass the formidable process of founding a small business. The scheme cuts through the jungle of administrative red tape usually required to launch a company, and dramatically lightens the heavy taxes and social charges companies pay. While other firms face set charges whether business is booming...
...Germany's national stereotype. Square-jawed, bronzed and urbane, the 47-year-old leader of the liberal Free Democratic Party doesn't exactly radiate humor. Asked what motivates him, he answers solemnly, "I burn internally." "He lives for politics," confirms close friend Hartmut Knüppel, who has known Westerwelle since they met through a youth wing of the FDP almost three decades...