Word: huntingtin
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...potential method for treating Huntington’s disease that might shed light on treatments for similar neurodegenerative diseases. The team—led by scientists at the Harvard-affiliated MassGeneral Institute For Neurodegenerative Disease (MGH-MIND)—identified a novel mechanism of clearing disease-causing mutant huntingtin protein from brain cells by modifying the protein structure for autophagic degradation, a natural degradation process in cells. The introduction of a specific molecular fragment known as an acetyl group into the mutant proteins—a process also known as acetylation—is the key to triggering...
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