Word: geneses
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But the somewhat artificial nature of this much anticipated milestone was underscored in two separate announcements last week. Writing in the journal Nature, a team of scientists working on the public project reported that they had finished decoding chromosome 21, the strand of DNA responsible for, among other things, Down...
But an estimated 95% of those letters fall into the category of "junk DNA"--molecular gobbledygook that spells nothing at all. Discovering where the actual genes begin and end, therefore, is key to understanding their functions--and DoubleTwist has taken a step in that direction. Using a Sun Microsystems supercomputer...
The result: a kind of road map to the genome, showing where along its long spirals of DNA the genes are located--65,000 of them with reasonable confidence, an additional 40,000 tagged more tentatively. For $10,000 a year, subscribers to DoubleTwist's website can read portions of...
In Down syndrome, for example, victims somehow acquire a third copy of the chromosome, whereas most people have just two. But exactly which of the 225 or so genes on chromosome 21 trigger the scores of physical and cognitive symptoms typical of the syndrome--or whether it's simply DNA...
Typically, gene therapists use viruses to deliver replacement genes into a patient's body. In a slight variation on that strategy, Fischer and his colleagues removed some of the children's bone marrow, sorted out the cells they needed and infected them with the gene-bearing virus. Then the researchers...