Word: geneses
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The genetic genie is out of the bottle, and like nuclear power, it can be used for good or evil. Soon it may be possible for doctors to manipulate genes and cure terrible illnesses, but the knowledge also may allow insurance companies, employers and others to make critical decisions based...
Sometime later, two more early-onset Alzheimer's genes were found, Presenilin-1 and Presenilin-2. Like APP, these genes were dominant; a child who received just one gene from either parent would inevitably get the disease. One of the most tragic examples involved a 4,000-member Colombian family...
In all, APOE4 may contribute to the development of more than 60% of all late-onset Alzheimer's cases. But that leaves the other 40% unaccounted for. And at this moment, many scientists, including Roses, are racing to identify still other Alzheimer's-susceptibility genes. Rudolph Tanzi, a geneticist from...
Selkoe is hoping that APOE4 and other as yet undiscovered susceptibility genes will produce clues that point to other potential compounds. For as he notes, Alzheimer's disease, no less than heart disease and diabetes, will almost certainly be found to have multiple causes. For example, the genes implicated so...
Scientists are struggling to identify environmental factors that may help protect those who carry susceptibility genes like APOE4. It's clear that these genes in and of themselves are not enough to cause Alzheimer's. Like aging itself, they are risk factors, which means that lifestyle choices may prove to...