Word: effexor
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...Prozac and other SSRIs in several studies. For instance, a review published in the Journal of Affective Disorders in February attributed 68% of the benefit from antidepressants to the placebo effect. Likewise, a paper published in PLoS Medicine a year earlier suggested that widely used SSRIs, including Prozac, Effexor and Paxil, offer no clinically significant benefit over placebos for patients with moderate or severe depression. Meanwhile, pharmaceutical companies maintain that their research shows that SSRIs are powerful weapons against depression. (Here's a helpful blog post that summarizes the debate...
...Researchers from the U.K., U.S. and Canada analyzed results for fluoxetine (better known by the brand name Prozac), venlafaxine (Effexor), nefazodone (Serzone) and paroxetine (Paxil or Seroxat) - all members of a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). The researchers' paper, published this week in the journal PLoS Medicine, claims that only patients who are diagnosed "at the upper end of the very severely depressed category" get any meaningful benefit from the widely prescribed drugs. For the others, the paper says, antidepressants are barely more effective than a placebo (although patients suffering from depression, like those suffering...
...Prozac has made to millions of people living with depression." Similarly, paroxetine producer GlaxoSmithKline warns, "This analysis has only examined a small subset of the total data available ... and this one study should not be used to cause unnecessary alarm and concern for patients." As a spokeswoman for Wyeth, Effexor's maker, points out, these were, after all, the same data the FDA reviewed before approving the drugs for public...
...closely monitor patients--especially young adults--for suicidal behavior when they begin drug treatment or change dosages. Doctors were also cautioned not to prescribe the drugs for mild depression without first trying talk therapy or other interventions. Finally, regulators issued a special warning about another kind of antidepressant, Effexor, saying it can cause irregular heartbeat and should be prescribed only by specialists...
...urged the manufacturers of 10 popular antidepressants to issue new, more stringent warning labels. The drugs named in the advisory are Prozac, Zoloft, Wellbutrin, Zyban, Paxil, Celexa, Effexor, Serzone, Luvox and Remeron. Together these pills racked up sales of about $12 billion worldwide in 2002. Some experts believe that it was their very popularity that concerned the FDA. Many doctors, the agency apparently fears, are giving out the pills too freely, without adequate monitoring...