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...SCAN images of the brains of recovering cocaine addicts reveal other striking changes, including a dramatically impaired ability to process glucose, the primary energy source for working neurons. Moreover, this impairment--which persists for up to 100 days after withdrawal--is greatest in the prefrontal cortex, a dopamine-rich area of the brain that controls impulsive and irrational behavior. Addicts, in fact, display many of the symptoms shown by patients who have suffered strokes or injuries to the prefrontal cortex. Damage to this region, University of Iowa neurologist Antonio Damasio and his colleagues have demonstrated, destroys the emotional compass that...

Author: /time Magazine | Title: ADDICTED: WHY DO PEOPLE GET HOOKED? | 5/5/1997 | See Source »

...week's Nature, Drevets and his co-workers reported that they had zeroed in on a tiny, thimble-size nodule of the brain located about 2 1/2 inches behind the bridge of the nose. Other scientists had already shown that this section of the brain, called the subgenual prefrontal cortex, plays an important role in the control of emotions. But Drevets, who has since moved to the University of Pittsburgh, discovered that it could also be the trigger point for both bouts of paralyzing sadness and the wildly euphoric highs of manic depression. "This area of the brain...

Author: /time Magazine | Title: ANATOMY OF MELANCHOLY | 5/5/1997 | See Source »

...measure how well cells are functioning, to probe the brains of dozens of people in the active throes of depression. Then they merged the results and compared them with those from a comparable number of normal patients. The pet scans showed a subtle but distinct difference: the subgenual prefrontal cortex was almost 8% less active in depressed patients than in the controls...

Author: /time Magazine | Title: ANATOMY OF MELANCHOLY | 5/5/1997 | See Source »

...mutant mice, the corpus callosum--the bundle of fibers which connects the two hemispheres of the brain--was almost non-existent. Additionally, the general pattern of connections in the rest of the cortex seemed to be highly altered...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

Tsai has found that the deficiencies in p35 mice closely mimic those found in several human neural disorders, such as lissencephaly, which produces the same type of seizures found in the mice and periventricular heterotopia and double cortex--which are caused by incorrect migration of cortical neurons...

Author: By Benjamin A. Stingle, | Title: The Road to Understanding Brains | 2/25/1997 | See Source »

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