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Kinks in proteins that form the nuclear matrix -- a dynamic scaffold to which DNA is attached -- may be particularly diabolical. The reason cancer cells typically have a swollen and misshapen nucleus, believes Johns Hopkins molecular biologist Donald Coffey, is that the proteins that form the nuclear matrix are misaligned in some fashion. Inside the matrix, notes Coffey, 50,000 to 100,000 loops of DNA are coiled like a Slinky, but the length of the loops, and where they begin and end, varies from tissue to tissue. The genes closest to the matrix are those that a particular cell intends...

Author: /time Magazine | Title: Stopping Cancer in Its Tracks | 4/25/1994 | See Source »

...another failed attempt to get all fivepetition issues onto the ballot, Rudd W. Coffey'97 proposed six individual measures, each ofwhich required a two-thirds vote by the counciljust for consideration and debate...

Author: By Todd F. Braunstein, | Title: Multiple Voting Possible In Council Referendum | 4/23/1994 | See Source »

...Five of Coffey's resolutions would have addedvarious combinations of the questions barred bythe executive board to the referendum ballot...

Author: By Todd F. Braunstein, | Title: Multiple Voting Possible In Council Referendum | 4/23/1994 | See Source »

...Coffey is really rooting for Arkansas, he said,because two of his high school friends are on theteam. He predicted that Arkansas will defeatConnecticut in the final game...

Author: By Emil J. Kiehne, | Title: NCAA Betting Pools Form In Dorms, Departments | 3/19/1994 | See Source »

...have a strong freshman team," Coffey said."There always is a possibility...

Author: By Emil J. Kiehne, | Title: NCAA Betting Pools Form In Dorms, Departments | 3/19/1994 | See Source »

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