Word: celle
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...drug developer, HIV is nothing but a thief. All the virus wants to do is break inside a healthy cell, steal its genetic machinery, and start profiting from the intrusion. To stop a thief, you need to throw a monkey wrench - or several - into his plans...
...each of which blocks a separate step in HIV's life cycle. The strategy is to build up a security detail of pharmacological agents that together thwart the virus at every turn, making sure that every receptor, protein and enzyme that the virus co-opts to sneak into a cell is covered...
...Currently available ARVs work at both the beginning and the end of the HIV life cycle; the most recently approved class in 2003, called fusion inhibitors, start early, working to block HIV's attempt to bind and infect healthy cells to begin with. Next come the two oldest classes of drugs, which prevent the virus from transforming its genetic material from RNA to DNA. And finally, jumping to the very end of HIV's mission, the protease inhibitor drugs keep the virus from making its final protein coat, which it needs to re-emerge from the infected cell in order...
...Pfizer's maraviroc, one of the two new compounds described this week, steps in just after HIV has successfully bound to a healthy cell; called an entry inhibitor, it blocks the virus from entering the cell and integrating its viral genetic material into the host cell's genome. In a study of more than 1000 patients who had developed resistance to at least three of the four ARV classes, twice the number of patients given maraviroc versus those taking placebo enjoyed undetectable levels of virus after eight months. The results were enough to convince Pfizer to apply for approval...
...Gordon says he was placed in a cell with a dim, unchanging light...