Word: celle
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...Many newer drugs target other pathways for tumor growth. Herceptin, introduced in 1998, interferes with a protein called epidermal growth factor by blocking the her2 receptor, a binding site that is found on the surface of many cells but is overabundant in about 25% of breast cancers. Other smart drugs interfere with the same growth factor, using slightly different chemical strategies to do so, and some have proved useful in a range of cancers. Gleevec, for example, which was approved in 2001, prevents growth factors from attaching to cancer cells and activating an enzyme called tyrosine kinase, which regulates cell...
Perhaps it was too good to last. Although it has been nearly 30 years since the first commercial cellular-phone network was launched, advertisers have yet to figure out how to get their messages out to mobile-phone users in a big way. There are 2.2 billion cell-phone subscribers worldwide, a total that is growing by about 25% each year, according to the Mobile Marketing Association (MMA). Yet spending on ads carried over cellular networks last year amounted to just $1.5 billion worldwide, a fraction of the $424 billion global ad market...
...games to lure thousands of fans to a website set up for mobile-phone access. "Our target audience was males ages 17 to 25," says Marcus Spurrell, Adidas regional new-media manager for Asia. "Their mobiles are always on, always in their pocket-you just can't ignore [cell phones] as an advertising tool." Says Geoffrey Handley, director of new business for The Hyperfactory, a Shanghai-based ad agency focused on handsets: mobile-phone marketing "has become as vital a platform as TV, online or print...
...rumors of match fixing linger. Former Pakistani fast bowler Sarfraz Nawaz believes that South Asia's bookmaking Mafia still manipulates results and that a bookie is probably behind Woolmer's murder. "Where there is gambling, there is money," he says, "and where there is money, there is murder." Using cell-phone numbers that they discard daily, and a series of codes when speaking to avoid police detection, bookies in Mumbai (formerly Bombay), Karachi and across the Arabian Sea in Dubai pull in hundreds of millions of dollars on scheduled series of big matches, and might have been keen to shut...
...actual twinning event took place. In the first scenario, the egg might have divided in two (without separating) and then each part fertilized by one sperm. Egg division before fertilization is very rare, says Minkin. The second, more likely possibility is that the egg fused with two sperm cells and created a triploid cell. Then, at the second-cell stage, each shed the chromosomes from each of the sperm - or did something to correct its chromosomal count, says Souter. "There are a whole host of potential mechanisms to explain this," she says, "but we really just don't know...