Word: trypsin
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Dates: during 1950-1959
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...controversial enzyme trypsin (TIME, Jan. 18) got a boost from doctors in Philadelphia General Hospital: injected into the buttocks, it is the best treatment yet for a black eye. It leaves the rainbow hues as gorgeous as ever, but it reduces swelling "in a manner verging on the dramatic...
...argument as to what the root cause of the trouble is. Some doctors believe that it lies in the mucous glands, which secrete an unusually thick, viscid mucus. This clogs the lung airways and also blocks the tiny ducts in the pancreas, so that its enzymes (notably trypsin) do not get through to the digestive tract. Others think the pancreas itself is at fault, and that its failure to produce enough enzymes causes both the intestinal trouble and the stickiness of the mucus...
...newborn, cystic fibrosis may reveal itself by the infant's inability to pass stools. Surgeons at Babies Hospital have devised a daring operation to open the intestine and flush it out with a trypsin solution. This technique is also being used in Boston under the guidance of Pediatrician Harry Shwachman, and in Los Angeles by Dr. Stephen Royce and his associates. It has prevented many deaths. After surgery, such a child will present the same problems as those whose symptoms develop a few months later in life...
...first Dr. Innerfield and his associates at Manhattan's Flower and Fifth Avenue Hospital gave trypsin to patients by intravenous drip. Other medical researchers objected that this method was unsafe, and a possible cause of blood clots. While not expressly conceding the point, Inner-field worked out another way of administering trypsin-intramuscularly...
...Innerfield cautions that trypsin must be used with care, and only in cases of acute inflammatory reaction where the cells undergoing changes are not irretrievably damaged. If this is done, he told his Toledo audience, intramuscular trypsin is "safe and effective." Asked one doc- tor: What about using trypsin for coronary thrombosis, a disease for which it was once thought to be valuable? Answered Researcher Innerfield, who is just beginning a long series of tests in this matter: "In three years I hope to be able to help...