Word: thyrotropin
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...Jacob K. Javits, 79, longtime (1957-81) Republican Senator from New York; for a new experimental treatment of amyotrophic lateral sclerosis, the progressive neuromuscular disorder also known as Lou Gehrig's disease; at Good Samaritan Hospital; in Los Angeles. Javits will be injected with extremely high doses of thyrotropin releasing hormone, an expensive ($2,400 per gram) drug that has produced dramatic but short-term improvements in ALS victims...
Psychiatrists have long suspected that there is a physiological basis for severe depression. They know that thyrotropin-releasing hormone (TRH), a substance released by the hypothalamus at the base of the brain, triggers the production of thyroid-stimulating hormone (TSH); now, they hypothesize that it may have another function as well. Drs. Arthur Prange Jr. and Ian Wilson of the University of North Carolina School of Medicine and the North Carolina department of mental health have found that TRH, which can be synthesized in the laboratory, seems to function as an antidepressant. They have used it experimentally to provide apparently...
...other highly evolved animals, the ordinary processes of life depend on other hormones which are non-sexual-such as insulin, the sparkplug hormone from the pancreas. Growth, according to the Carnegie Institution's Oscar Riddle, is due to a combined action of two pituitary hormones, prolactin and thyrotropin...
...combined action of two or more. This phenomenon is called "synergism." The work of Evans and others convinced many a gland man that the pituitary secreted a "growth hormone." Riddle's researches, however, tend to show that growth is a synergic response to two hormones, thyrotropin and prolactin. He also believes that this same pair get together in another synergism to maintain body heat...
...sources of confusion were less well understood than now, it was fashionable to attribute every pituitary reaction to a separate hormone. Riddle exposed some of these as "ghosts." He believes the number of definitely established front-lobe hormones to be small-five at most. These possible five are 1) thyrotropin, the thyroid-stimulator; 2) adrenotropin, which acts on the adrenals; 3) and 4), "FSH" and "LH" which affect the ovaries or testes; 5) prolactin...
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