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...just like ordinary mice, with no evidence of seizures or convulsions, according to Tsien. That's critical. The NMDA receptor shows up throughout the brain, and though calcium is crucial to learning and memory, too much of it can lead to cell death. That's what happens during a stroke: when brain cells are deprived of oxygen, they release huge amounts of glutamate, which overstimulates nearby NMDA receptors and kills their host cells. Nature may have designed NR2B-based receptors to taper off in adult brains for a reason. Some scientists fear that the altered mice may be prone...

Author: /time Magazine | Title: Smart Genes? | 9/13/1999 | See Source »

There remains the nagging question of what it means precisely to say that Tsien & Co. have created a smarter mouse. "What is it that is being tested?" asks Gerald Fischbach, director of the National Institute of Neurological Disorders and Stroke. "That's the problem with mouse behavior. It's not clear that we're talking about the same thing when we talk about learning in a rodent and learning in a human...

Author: /time Magazine | Title: Smart Genes? | 9/13/1999 | See Source »

...last week that Bill and Hillary Clinton had settled on a house just up the street from me in Chappaqua, N.Y., the first thing I did was hop in my car and do a drive-by. How can I deny it? Half the village was there. With the stroke of a pen (and imminent transfer of $1.7 million), the First Couple have managed to turn a quiet suburban cul-de-sac into the surest spot in town to be seen...

Author: /time Magazine | Title: Prez N the Hood | 9/13/1999 | See Source »

LESS IS MORE Aspirin, the oldest of wonder drugs, has been recommended for years as a way of preventing a recurrence of stroke. But what about aspirin for folks who've never had a stroke? It's O.K. to take it within limits: up to one tablet a day seems enough to protect against common thrombolytic stroke, but two tablets a day doubles the risk of hemorrhagic stroke, an event far more likely to be fatal...

Author: /time Magazine | Title: Your Health: Sep. 13, 1999 | 9/13/1999 | See Source »

...past 25 years, doctors in the U.S. have warned their patients about the dangers of high blood pressure, a generally symptomless condition that increases the risk of heart disease, kidney failure and stroke. By aggressively treating folks whose readings exceed the normal limit of 140/90 mm Hg at rest, physicians have prevented millions of premature deaths and untold suffering. But it looks as if we've stopped getting the message. A national health survey released two years ago showed that blood-pressure rates are no longer falling; at the same time, the incidence of stroke has started to rise...

Author: /time Magazine | Title: Pressure Check | 8/30/1999 | See Source »

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