Word: streptomycin
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...John E. McKeen said: "Pfizer never engaged in a conspiracy, never misused its patents, never fixed prices, and wields no monopolistic powers." Although recognizing that the newer wonder drugs do command high prices, the manufacturers long since have cut the price of the older standbys, such as penicillin and streptomycin, so low that they are added in large amounts to animal feed. Said Bristol-Myers' President Frederick N. Schwartz: "Our average profit on all antibiotics sold in 1957 was less than 1? per dose...
What to Do? Most of the dangerous staph are immediately found to be resistant to penicillin and streptomycin. They show descending orders of resistance to the tetracyclines (Aureomycin, Terramycin, Achromycin) and chloramphenicol (Chloromycetin). Strains have emerged that show varying resistance to still newer antibiotics. Strangely, nobody knows exactly how severe the problem is because most deaths caused by staph are not so listed. If a patient admitted for heart surgery dies of a staph infection, his death is attributed to the original heart trouble. Example: in Seattle and surrounding King County, only four deaths...
...doctors as increasingly serious. Said one: "We have no explanation as yet. but it seems that the virus is now stronger than the previous week." Abandoning their now ineffective treatment of aspirin or linden-flower potion, health officials fought the virus, identified as "Japan 305," with such antibiotics as streptomycin and achromycin...
Experts agree that three combinations are justified: 1) streptomycin with other drugs (such as isoniazid) to discourage the appearance of resistant tubercle bacilli; 2) penicillin with streptomycin for inflammation of the heart lining (endocarditis); 3) tetracycline (or related antibiotics) with nystatin, not routinely but in some cases, to guard against secondary infection with the fungus monilia. Granting exceptions such as these, the Archives' editorialists conclude: "It is our firm conviction that the promotion and sale of such combinations should be discouraged...
From Cook County Hospital, Dr. Daniel S. Kushner reported that a related germ, Mycobacterium fortuitum, can cause a disease like tuberculosis in mice. It is resistant to streptomycin and PAS (para-aminosalicylic acid) but it can be killed by isoniazid and also by the antibiotic tetracycline...