Word: streptomycin
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...week, Cornell's Dr. Ralph Tompsett got up in London's cavernous, dingy Central Hall and passed the news to 400-odd experts gathered for a British Empire conference on TB. Sum of the findings: isoniazid is the only drug that belongs in the same class with streptomycin for effectiveness against tuberculosis. In most respects it is as good as streptomycin; in some ways, better...
...meningeal, in which the bacilli attack the covering of the brain and spinal cord, and miliary, in which they spread throughout the system. Untreated, both meningeal and miliary tuberculosis commonly kill within two or three months, and about one-third of the victims get only temporary help from streptomycin. To researchers, a patient with miliary TB is like a human test tube. The course of his disease is so predictable that they can tell just what a drug is doing...
Almost as heartening are the early results in tuberculous meningitis. Dr. Clark has treated several cases which had relapsed after courses of streptomycin. After 80 days of streptomycin, eight-year-old Elsie still had a fever; she had TB germs in her spinal fluid; she was mentally clouded and suffering spasms. Within a month, isoniazid changed all that, and not long after, Dr. Clark was able to take Elsie to the circus...
...will take six months for doctors to render a confident verdict on Rimifon, Marsilid and Nydrazid. Meanwhile, there is a sobering lesson in the history of anti-TB drugs: dozens have come and all but one "wonder drug" (streptomycin) have gone, but TB remains...
...acts, it will want to know whether the new drugs, given over long periods, will prove too poisonous for the patient to tolerate. Doctors want to know much more. Will the germs learn to resist the new drugs and live with them, as they often do with streptomycin? If a patient's sputum is free of germs a month after treatment is started, will it still be clear a year later, or will he suffer a shattering relapse...