Word: reprogramming
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HSCI co-director Douglas A. Melton and his colleagues have successfully created induced pluripotent stem (iPS) cells using a chemical that can replace two of the four potentially cancer-causing genes previously needed to reprogram adult cells into a mutable state. The findings, published Sunday on the Web site of the journal Nature Biotechnology, open another avenue for researchers hoping to create iPS cells that are safe for treating human disease...
...technique allows scientists to genetically manipulate a patient’s cells—typically skin cells or blood cells—and reprogram them into a pluripotent state. Like embryonic stem cells, these iPS cells are then capable of morphing into any type of body tissue...
...cautionary tales. Most Democrats, and some Republicans, have pushed for full federal funding of embryonic-stem-cell research, an issue so hot it tipped some close 2006 midterm races. But since then, the biggest breakthroughs have come in techniques that do not use embryos at all but instead reprogram adult cells. Do proponents look reckless for putting all their emphasis on embryos, which even some prominent scientists find morally troubling? Or prescient, because the basic knowledge gleaned from embryo research is what may help make it unnecessary someday...
...technique allows scientists to manipulate a patient’s cells genetically—typically skin cells or blood cells—and reprogram them into a pluripotent state. Like embryonic stem cells, these iPS cells are then capable of morphing into any type of body tissue...
...Lead author of the paper Qiao "Joe" Zhou, a post-doctoral fellow working in Melton's laboratory, said that finding the correct combination of the three transcription factors to reprogram the cell that makes gut enzymes in mice into a more useful pancreatic cell was the result of three years of repetitive lab work...