Word: receptor
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...happens, drugs that block the mGluR5 receptor already exist. Hagerman's group and a team at Rush University in Chicago are about to test one such drug, fenobam, as a treatment for Fragile X. Bear, meanwhile, has founded a company called Seaside Therapeutics that hopes to begin human safety tests of another drug as early as next year. Both researchers believe that a safe and effective mGluR5 inhibitor would help both children and adults with Fragile X Syndrome, though drug treatment early in childhood would seem to offer the most promise...
...perform markedly worse on the task at hand: They selected the good symbols from the bad about as often as participants who didn't have the allele. The results suggest that learning - though influenced by dopamine - is a complex process that involves much more than one kind of brain receptor. "It's just one factor that may contribute to some problems that might arise in some people," says Markus Ullsperger, a co-author of the Science paper, based at the Max Planck Institute for Neurological Research in Cologne. "I think you can compensate for many things without even noticing...
...says. In men, "because it's not on their radar, [a lump] might not be something they get seen immediately." In men, as in women, treatment usually includes surgery followed by some combination of radiotherapy, chemotherapy and - because almost all men with breast cancer have tumors characterized as hormone-receptor-positive - hormone treatment...
...Asian women, as well as black women in the U.S. and Africa, are at higher risk of developing a more aggressive form of breast cancer known as estrogen-receptor negative, or ER-negative. That illness strikes an average of 10 years earlier than the other variety and is indifferent to drugs that block estrogen since it isn't fed by estrogen in the first place. Worse, research findings released in June 2006 showed that 40% of premenopausal African-American breast-cancer patients have an even more dangerous form of ER-negative cancer called the basal-like subtype, resistant not only...
...particular group of dopamine receptors, for example, called D3, seems to multiply in the presence of cocaine, methamphetamine and nicotine, making it possible for more of the drug to enter and activate nerve cells. "Receptor density is thought to be an amplifier," says Frank Vocci, director of pharmacotherapies at NIDA. "[Chemically] blocking D3 interrupts an awful lot of the drugs' effects. It is probably the hottest target in modulating the reward system...