Word: pruessner
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More recently, researchers have found that subjects with low self-esteem are more vulnerable to stress. Jens Pruessner at McGill University in Montreal believes that the hippocampus, a finger-size structure located deep in the brain, is at least partially responsible. It turns out that the hippocampus, which helps you form new memories and retrieve old ones, is particularly sensitive to the amount of cortisol flooding your cerebrum. So when cortisol levels begin to rise, the hippocampus sends a set of signals that help shut down the cortisol cascade...
Using several different types of brain scans, Pruessner has shown that people who test below average on self-esteem also tend to have smaller-than-average hippocampi. The differences become clear only when you compare groups of people, Pruessner notes, so you can't look at any single person's brain scan and determine whether he or she has low self-esteem. But when you look at overall results, they suggest that a smaller hippocampus simply has more trouble persuading the rest of the brain to turn off the stress response...
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