Word: p35
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Tsai and her team have recently isolated a gene in mice, called p35, which appears to play an integral part in the formation of the cortex...
...p35 mutants, which were seemingly normal at first, became consistently abnormal when grown...
...results of the finding indicate that p35 is an essential part of a proposed signaling pathway that has been thought to guide neural development...
Tsai has found that the deficiencies in p35 mice closely mimic those found in several human neural disorders, such as lissencephaly, which produces the same type of seizures found in the mice and periventricular heterotopia and double cortex--which are caused by incorrect migration of cortical neurons...
Although all the evidence is not in yet, Tsai hints that her current work is showing that there are strong ties between p35 and these degenerative diseases, raising hopes that more effective treatments for them might be found in the future...