Word: isner
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Stokes chose to survive. He volunteered to take part in a novel clinical trial about to be conducted on heart patients by Dr. Jeffrey Isner at the St. Elizabeth Medical Center in Boston. To his surprise, he was accepted. Last May he flew to Boston, where a solution containing billions of copies of a gene that triggers blood-vessel growth was injected directly into his heart...
...feeling better and now, at 58, he is back at work on a normal, nitroglycerine-free routine. "I ride horses and I run tractors," he says. "You have to be in pretty good shape to do what I do." As it turned out, all 16 heart patients in Isner's trial showed improvement, and six are entirely free of pain...
...heart-patient trial, St. Elizabeth's Isner found a novel way around the delivery problem. Eschewing virus carriers, he fashioned a construct called "naked DNA." It consists of part of a human gene called VEG-F, which stimulates the growth of blood vessels, and includes its signal segments. These segments, Isner explains, "order the cell, once it has manufactured the gene product, to export it from the cell...
Some of that evidence has been provided by Cardiologist Jeffrey Isner of the New England Medical Center in Boston, who suspects that heart damage from cocaine occurs more often than most specialists believe, partly because doctors seldom ask heart patients if they have used drugs. "There are still superb cardiologists," says Isner, "who are surprised to find out that cocaine can cause a lethal cardiac event." In a paper published last October in Circulation, the journal of the American Heart Association, Isner reported on seven people, ages 20 to 37, who used cocaine shortly before suffering apparent heart attacks...
...Court of Appeals, Fifth Circuit, Judge Edwin Yates Webb, in the case of the U. S. v. Isner, declared he had been a member of the Congress which passed the Volstead act, recalled well the debates on the subject, knew that it was the intention of Congress to define "non-intoxicating" at "non-intoxicating in fact...