Word: interleukin
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Dates: during 2000-2000
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...interactions between helper T cells and APCs to develop antibody drugs against lupus and RA. Their anti-RA antibody selectively switches off T cells involved in autoimmune responses by binding the CD4 molecule on their surfaces. Amgen, of Thousand Oaks, Calif., has developed a drug that works by blocking Interleukin-1, another molecule that promotes inflammation...
...been enough success with interferon, says Dr. Ronald Blum, director of the Beth Israel Cancer Center in New York City, to make the immune-boosting drug be considered a standard of care. And, he adds, "for those who can withstand the short but very toxic inpatient treatment program, interleukin-2 can lead to significant reductions in tumor size." In most advanced cases, however, all that these and other valiant efforts can do is buy a few months, maybe a couple of years at the outside...
...HELP More hope on the AIDS front. A new study shows that adding the immune-system stimulant interleukin-2 to the usual brew of AIDS drugs can more than double T-cell counts in patients infected with HIV. Plus, in a surprise for researchers, blood levels of HIV dropped slightly too. Both findings are decidedly encouraging, though it's too early to know for sure whether revving up T cells this way will delay the onset of full-blown AIDS. And there's a price: the interleukin-2 was injected twice daily for five days every eight weeks, during which...