Word: hilleman
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...cells or fibroblasts cultivated in the laboratory. But less conventional routes are also being explored. One is to provoke the body into boosting its own manufacture of IF by injecting inducers, usually double strands of synthetic RNA* that resemble viruses. The method was tried in the 1960s by Maurice Hilleman and others at the Merck Institute. But inducers were virtually abandoned when they proved largely ineffective and, on occasion, highly toxic. A new inducer, though, has been showing some promising early results...
...most ways they are so similar that people vaccinated within the past 12 months against A/Victoria, or who actually had that disease, have some degree of immunity against A/Texas, which first appeared in 1977. But, explains Merck & Co.'s Maurice R. Hilleman, their antibody level against A/Texas is only a fraction, perhaps a quarter or an eighth, of their level against A/Victoria...
Last week a team at the Merck Institute for Therapeutic Research reported that it has succeeded in doing this in mice and rabbits, and is ready to try to extend the method to man. Chief of the investigators is Dr. Maurice R. Hilleman, already famed for his work in developing a mumps vaccine (TIME, July 1, 1966) and Enders measles vaccine. The first of his group's reports appeared under the prestige imprint of the Proceedings of the National Academy of Sciences...
...Hilleman's group reasoned that since it seems to be the nucleic acid in the virus' core that provokes natural interferon output, something like a harmless form of nucleic acid might stimulate the increased production they were seeking. They tested helenine, extracted from a mold related to those that make penicillin and already known to have antiviral properties (though no one then knew why). Extraordinarily complex extraction procedures yielded a pure ribonucleic acid (RNA). But this was no ordinary RNA, such as occurs in the cores of many viruses in molecules of single strands. This proved...
...lucky coincidence, that search ended when five-year-old Jeryl Lynn Hilleman came down with mumps. Jeryl Lynn is the daughter of Dr. Maurice R. Hilleman, head of the virology team at Merck Sharp & Dohme Institute for Therapeutic Research, which had been hunting for years for a mumps virus that would grow well in the lab and lose its virulence, while still retaining its power to give immunity. Dr. Hilleman and Dr. Eugene Buynak found that Jeryl Lynn's virus was just what they wanted...