Word: hematologist
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Dates: during 1980-1989
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...living in a new age of medicine." That was the appraisal last week of Dr. Robert Gale, a UCLA hematologist and veteran of the medical team that treated victims of the Chernobyl nuclear disaster last year. Gale had just returned from Rio de Janeiro, where with an international group of physicians he had spent ten days treating six badly irradiated victims of a bizarre accident in Brazil with an experimental drug called GM-CSF. "When it comes to these disasters," concluded Gale, who will soon return to Rio, "all the handbooks on treatment will have to be rewritten...
Victims of AIDS must not only combat the virus that causes the disease but must also fend off potentially fatal infections that overrun their weakened immune systems. A team of researchers in Boston and Los Angeles, led by Hematologist Jerome Groopman of New England Deaconess Hospital, reported in the New England Journal of Medicine last week that a genetically engineered version of a naturally occurring hormone partially restored depressed immune systems in 16 AIDS patients...
...experienced mild and transient nausea and vomiting, doctors worry about administering a toxic anticancer drug forlong periods. Another concern: What other genes are being altered? A fear is that the drug approach may inadvertently switch on recently discovered cancer genes that apparently lie dormant in most people. Nonetheless, noted Hematologist Edward Benz of Yale University School of Medicine, who wrote an accompanying editorial in the NEJM, "this research represents a major new step in treating disease and demonstrates beyond doubt that genetic manipulation has come to the bedside...
...July, U.C.L.A. Hematologist Martin Cline and colleagues at Jerusalem's Hadassah Hospital on Mount Scopus and at a clinic of the University of Naples performed gene transfers on two female patients. Both had severe thalassemia, an inherited blood disorder in which the bone marrow produces red cells with defective hemoglobin (the molecule that carries oxygen to body tissues). Victims need frequent blood transfusions, but this leads to a buildup of iron in the body, particularly the heart, that can eventually cause death...
Cline says that safety guidelines similar to those in the U.S. were followed in Israel and Italy. But, observed one Israeli hematologist, "if this type of research is forbidden in the U.S., a world model for such work, I would hesitate to approve it in my own country." In Washington, the National Institutes of Health's Office for Protection from Research Risks has asked U.C.L.A. for a full report. Declares Cline: "After consideration of all the scientific and moral aspects, I'd do it again...