Word: geneses
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Scientists have known for more than two decades that cancer is a disease of the genes. Something scrambles the Dna inside a nucleus, and suddenly, instead of dividing in a measured fashion, a cell begins to copy itself furiously. Unlike an ordinary cell, it never stops. But describing the process...
Until now. According to a report in the current issue of Nature, a team of scientists based at M.I.T.'s Whitehead Institute for Biomedical Research has finally managed to make human cells malignant--a feat they accomplished with two different cell types by inserting just three altered genes into their...
The dramatic new result traces back to a breakthrough in 1983, when the Whitehead's Robert Weinberg and colleagues showed that mouse cells would become cancerous when spiked with two altered genes. But when they tried such alterations on human cells, they didn't work. Since then, scientists have learned...
The strategy worked. The scientists took connective-tissue and kidney cells and introduced three mutated genes--one that makes cells divide rapidly; another that disables two substances meant to rein in excessive division; and a third that promotes the production of telomerase, which made the cells essentially immortal. They'd...
Often in medicine, before you can find out how to destroy the enemy, you first need to know how to build it. And so it came as important news on Thursday when the science journal Nature revealed that a team of researchers had succeeded for the first time in turning...