Word: genese
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Often disregarded as a fake illness, RLS gained new ground in the scientific community this week after researchers at Emory University in Atlanta and the Iceland-based company DeCODE Genetics identified a gene variant that increases risk for the condition. The team reported their findings in the current issue of...
For years, many stem-cell researchers sought to accomplish that through nuclear transfer-transplanting an adult cell's nucleus into an egg that had been emptied of its own genetic material. This process is expensive and difficult, and so far no one has been able to pull it off in...
No one expected those opportunities to come so soon. Trying to discover the right combination of genes that would reprogram adult cells was a scientific fishing expedition in a deep ocean. In early 2004 Yamanaka had worked up a list of 24 possible genes he thought were instrumental in cell...
Fortunately, Yamanaka had one student who was brave-or at least, knew when to say yes to his boss. Takahashi spent endless hours screening the candidate genes. "Perhaps this is not something Kyoto University should know, but I worked 365 days a year," Takahashi laughs. Using retroviruses to deliver the...
That the process proved so straightforward shocked Yamanaka. Scientists had assumed that reprogramming would likely require a complex arrangement of far more genes. "We were very surprised," he says-and with the Hwang debacle on their minds, "we were very worried." Yamanaka had another researcher repeat Takahashi's work, and...