Word: fragmenting
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Dates: during 2000-2000
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Other companies are focused on boosting the immune system with vaccines that can direct it to target cancer cells. A vaccine developed at Memorial Sloan-Kettering binds a protein from a limpet to seven different types of sugars and a protein fragment found only on cancer cells, and saponin, a soap-like derivative from a South American tree. This witch’s brew serves to annoy the immune system, revving it up enough to attack cancer cells that are carrying the same sugars and protein fragment...
...things make me say that Lemieux is on an equal plateau with Gretzky. One, Lemieux returned from numerous injuries and even cancer, and was still the best player in the league. Gretzky never went through a fragment of the injuries that Lemieux...
...Some principles are not negotiable: the concept of national unity. If the guerrillas get what they want, it will fragment the country...
Then, last year, the Amyloid People staged a surprise attack. First, researchers at Elan Pharmaceuticals of South San Francisco stunned their colleagues by reporting that they had taken mice genetically engineered to develop plaques and vaccinated them with a fragment of beta amyloid. Twelve months later, seven out of nine mice remained plaque free. Then the Elan team vaccinated year-old mice whose brains were riddled with plaques. Result: the plaques started to melt away. Elan quickly drew up plans to test the vaccine in humans...
That same year, other research teams, including one led by Selkoe, created yet another stir. They zeroed in on the elusive enzymes that snip the beta-amyloid fragment from the precursor protein. "We had the paper, and now we had the scissors," says Selkoe. If he is right, one of those scissors, gamma secretase, may actually be the presenilin-1 protein. Whatever the true identity of gamma secretase turns out to be, pharmaceutical companies are rushing to develop drugs that block it. Bristol-Myers Squibb has already started safety tests of one such compound and hopes to expand its study...