Word: fragmentation
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...buildup of a protein known as beta amyloid. The chief constituent of the scarlike plaques found in the brain of Alzheimer's patients, beta amyloid is made by nerve cells when beta and gamma secretase execute a one-two snip that cuts a larger precursor protein into a shorter fragment. Sometimes the fragment is 40 units long, sometimes 42. The slightly longer variant, scientists have found, is directly toxic to nerve cells. Among other things, it appears to stimulate the release of oxygen free radicals, thereby setting off in the brain a destructive biochemical cascade...
...cells it competes with a third enzyme known as alpha secretase, whose activity, some think, may help protect the brain against Alzheimer's disease. When alpha makes the first cut in the precursor protein, gamma secretase makes a second cut that produces not beta amyloid but an innocuous protein fragment known as p3. Elan and Pharmacia, based in Peapack, N.J., among others, are actively working to develop beta secretase inhibitors...
Other companies are focused on boosting the immune system with vaccines that can direct it to target cancer cells. A new vaccine developed at Memorial Sloan-Kettering binds a protein from a mollusk called a limpet to seven different types of sugars and a protein fragment found only on cancer cells. The vaccine is then mixed with saponin, a soaplike derivative from a South American tree. This witch's brew serves to annoy the immune system, revving it up enough to attack cancer cells that are carrying the same sugars and protein fragment...
Other companies are focused on boosting the immune system with vaccines that can direct it to target cancer cells. A vaccine developed at Memorial Sloan-Kettering binds a protein from a limpet to seven different types of sugars and a protein fragment found only on cancer cells, and saponin, a soap-like derivative from a South American tree. This witch’s brew serves to annoy the immune system, revving it up enough to attack cancer cells that are carrying the same sugars and protein fragment...
...things make me say that Lemieux is on an equal plateau with Gretzky. One, Lemieux returned from numerous injuries and even cancer, and was still the best player in the league. Gretzky never went through a fragment of the injuries that Lemieux...