Word: drawbacks
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Dates: during 1990-1999
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...there was any drawback to last night's game, it was the return of the Third Period Blues, a syndrome in which the Crimson inexplicably seems to enter a state of hibernation later in the game and relies on its defense and goalie J.R. Prestifilippo...
...forbidding Margaret Atwood has turned a notorious Canadian murder case from the mid-19th century into a shadowy, fascinating novel. Alias Grace (Doubleday; 468 pages; $24.95) is less combative and ideological than such earlier Atwood novels as The Handmaid's Tale and The Robber Bride. That's not a drawback. There's a teasing, unknowable mystery at the heart of the story, which is the same one faced by jurors in Toronto in the 1840s: to what extent was Grace Marks, a pretty, nearly 16-year-old servant girl, guilty of the murder of her employer, Thomas Kinnear...
Although Hyman and Rawlins hope for a change in council demographics, one potential drawback is the loss of the many councillors who will not run for re-election...
Useful as they are, these drugs share the same serious drawback. Because they target all dividing cells, they also kill off normal tissue in the skin, hair and bone marrow. The next generation of anticancer agents, however, promises to be much more selective. By targeting oncogenes, for example, researchers hope to switch off the signals that prompt cancer cells to divide in the first place. Particularly promising is a class of drugs known as farnesyltransferase inhibitors, which have been shown to shrink tumors while sparing normal tissues. "Oncology is not a profession that inspires optimism," admits Dr. Allen Oliff, director...
...affinity for serotonin receptors, Clozaril is largely free of the Parkinsonian side effects (the "Thorazine shuffle" and so on) that plague the classic antipsychotic drugs. It was also the first drug to ameliorate symptoms of schizophrenia that are resistant to other drugs. But Clozaril has a major drawback: a life-threatening side effect called agranulocytosis, a drastic drop in white blood cells that requires patients to undergo expensive weekly blood monitoring...