Word: chemo
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...account for the discrepancy in chemotherapy’s relative effectiveness. “In tumors that depend on hormonal mechanisms to drive them, therapy that targets the hormones has a huge effect. As a result, there is not a lot of room for the added effect of chemo,” Garber said. Because hormone therapy drugs like tamoxifen reduce an ER-positive patient’s death rate by 30 percent, women with ER-positive tumors receive less benefit from chemotherapy than women with ER-negative tumors that do not respond to hormone therapy. The study results present...
...Charlie's logic went something like this: "I'd rather you kill me than this cancer and you might learn something in the process - so bring it on, Doc". He was a very strong, young man and figured he could take a lot more chemo, a lot more surgery and a lot more radiation than most patients. It wasn't that he had the "we're going to beat this thing, Ruff" attitude. He expected death, pretty soon, but he wanted to be the victim of medical target practice, not what the ancients called the crab...
...After the first round of "cherry picking" - open-chest surgery cutting out the chunks of his lung that held tumors big enough to see and feel - he started an untested chemo regimen; he carried around a battery-powered pump on his belt that fed the nauseous chemicals into his veins around the clock. It was during this period that he came to my office, told me his story and asked if I could do anything about his limp. He had a painful knee. "You have all this going on and you want me to take out a torn cartilage...
...After clearing out the mysterious fluid, the rest of the operation was routine, as was his follow up. The knee got better. I asked every oncologist I knew if they ever heard of this as a side-effect of chemotherapy. Some of the chemo they were giving Charlie was cherry-red - the thought was that somehow the tissue lining the knee (synovium, that normally makes the tan joint fluid) had been taking the red chemo molecules and changing them into something fluorescent green. This was just a guess though - the red stuff doesn't go green in any known situations...
What was the treatment like? Patients first underwent surgery to clear the abdominal area?including around the liver, spleen and under the diaphragm?of as much cancer as possible, followed by 18 weeks of chemo...