Word: aminopterin
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...death in several animals. But Goldstein says excessive vitamin D is unlikely, since blood tests would show high calcium levels, which haven't been found. Says an FDA spokesman: "Our analysis of the premix indicates that vitamin levels were appropriate." Other theories floated to explain the bizarre deaths are aminopterin, or rat poison, which would cause the kind of kidney damage seen. An Albany lab found the substance in two pet food samples of canned foods, but the FDA has ruled these out because no other lab has been able to confirm the results...
...Sidney Farber of Boston Children's Hospital and the Children's Cancer Research Foundation. Knowing that leukemic cells are avid for the vitamin folic acid, he began in 1947 to treat child victims of acute leukemia with analogues of folic acid. Lederle Laboratories sent Dr. Farber two, aminopterin and amethopterin. which soon brought about improvement in most of the children. But after weeks or months, their disease became resistant...
...physiologist and biochemist, director of research for the Lederle Laboratories (American Cyanamid Co.); in Pearl River, N.Y. As a Harvard graduate student, he pioneered in studies on muscular contraction, after going to Lederle concentrated on folic acid (part of the vitamin-B complex), helped develop its derivatives, teropterin and aminopterin (now being used to fight cancer), directed research that produced the new antibiotic, aureomycin (a cure for serious infections untouched by penicillin or streptomycin...