Word: warfarin
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Recognized for its anticoagulant abilities, warfarin was later used in 1955 to treat Eisenhower after a heart attack. Now, warfarin is used in rat and mice pesticides...
...Warfarin works as a blood thinner by interfering with VKOR, a bacterial version of the human enzyme that recycles vitamin K in the liver. Through the recycling process, clotting factors are produced and secreted into the blood, piling up to act as coagulant agents...
Coagulation, which stops the loss of blood at vascular injury sites, is essential for the process of stopping bleeding, or hemostasis, but it can be dangerous in the case of blood clotting complications like deep vein thrombosis. Warfarin, an anticoagulant, inhibits the function of the VKOR enzyme...
...addition to its role as an anticoagulant, warfarin inhibits the VKOR homologue of mycobacterium tuberculosis—a productive agent of tuberculosis...
...caveat” of using warfarin to inhibit tuberculosis growth is the need to apply very high concentration of the drug to produce desired results—and high dosages of the drug may cause a patient to bleed to death, according to graduate student and lead researcher Rachel Dutton...