Word: painful
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Dates: during 1980-1989
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...More pain probably lies ahead. Louis-Dreyfus has his work cut out for him -- and a compensation package geared to inspire success. On top of a reported salary of $785,000, Louis-Dreyfus will control stock options worth at least $3 million. That value will rise substantially if he does his job well. Earlier this month, Louis-Dreyfus pledged to boost the value of the company's shares, which have traded as high as $10.70, from their current price of $4 to at least $7.85 within three years. More than another increase in its global reach, that is the kind...
...Lane suffered his second head injury in as many weeks. A stick to the side of the eye required six stitches, and the related head pain and vision problems have kept him out of the lineup since...
...most promising of several drugs to combat addiction that are being tested is buprenorphine, a pain reliever that in early trials has shown clear advantages over methadone as a treatment for heroin addiction. Under development by a team at Yale University, the drug, like methadone, induces a generalized feeling of contentment rather than heroin's precipitate rush and euphoria. It is at least as effective as methadone in easing physical withdrawal and reducing cravings, and it is significantly more potent in blocking heroin's high if the addict tries to shoot up again. Unlike methadone, buprenorphine is relatively nonaddictive...
Still, scientists are not expecting miracles, particularly in battling cocaine addiction. Unlike heroin, which acts on the pain-killing endorphin system alone, cocaine engages three separate neurotransmitter systems: those based on dopamine, serotonin and norepinephrine. Taken together, these networks govern the human ability to experience pleasure, from watching a sunrise to having sex. Blocking all these pleasure centers -- as methadone blocks the heroin high -- would literally take the joy out of life, says Yale's Kosten. "We'd turn out automatons." Addicts trying to quit cocaine go through a stage called anhedonia, a sort of spiritless limbo that typically drives...
Simpson writes that the poets could not escape their pain, even after they had completed a substantial work. Berryman and Schwartz both experienced writer's block, and often the two would panic when their work had gotten a bad review, she writes...