Word: laborites
(lookup in dictionary)
(lookup stats)
Dates: during 1960-1969
Sort By: most recent first
(reverse)
...Laborit who ferreted out the unsuspected nerve-center-depressant properties of chlorpromazine, the wonder drug of 1954, which opened up the new field of psychopharmacology (the use of drugs to influence the emotions). It was Laborit who found the formula for the sleep inducer gamma-OH, which has no unpleasant aftereffects...
With no government or university support, Laborit works, with eleven assistants, in the same crowded four-room lab he built eight years ago, and maintains with income from his discoveries...
...greatest income yet may come from Ag 246, which was concocted-with the help of Chemist Camille Wermuth and longtime aide Dr. Bernard Weber-as an improvement on a Laborit arthritis drug. By molecular manipulation, Laborit and his colleagues created 40 variants of the arthritis medicine, then started systematically to test each one. On only the second try, they found what they were looking for. They called it Ag 246; it is also known as MEMPP, short for chlorhydrate of morpholino-ethyl-2 methy14 pheny16 pyridazone...
After 21 years of cautious testing Laborit reports that the intravenously administered drug enhances the effect of anesthetics, thus lowering the amount necessary for a patient, and thereby lowering the danger. It reduces inflammation, has an anticonvulsive effect useful in treatment of epilepsy, and has a suppressing effect on symptoms of Parkinson's disease. "But it is Ag 246's analgesic or pain-killing qualities that are perhaps most promising," says Laborit. Operations have already been carried out using the new drug with no anesthetic. The patients felt no pain but remained awake throughout the operation, carrying...
Such stunning successes are possible, explains Laborit, because of its ability "to depress all that which has to do with affectivity, with passions, rage-the reactions of the more primitive part of the brain-yet leave the advanced centers functioning." American and French companies are already planning to market his patented discovery within two years, after the continuing search for further uses or undesirable side effects has been completed. But even now, says the confident Laborit, "it would seem that one could say without being too optimistic, that pain in all its forms will be called upon to disappear while...